WHAT DOES METHADONE VS BUPRENORPHINE IN PREGNANCY MEAN?

[61] Like several other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with distinct potency. Dextromethadone, that's considerably less powerful as an opioid, is a lot more strong at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone contains a lower affinity, with an IC